D-Mannose Is Safe For Long-Term Use
The review, published in August 2022, includes research on D-mannose for the past 32 years: “In this paper, we systematically reviewed the published data on the effect of D-mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. PubMed/Medline and EMBASE databases were searched, from 1990 to January 2022.”
Here are the facts from the review:
First, D-Mannose is a natural product that our system produces on its own. “D-mannose is a monosaccharide naturally produced by the body from glucose. It is present in the body cells and in some foods.”
As the illustration shows, D-Mannose is chemically identical to glucose.
Second, there is no effect on human metabolism after long-term use of D-mannose. Here is the technical explanation as to why: “At least 90% of ingested D-mannose is absorbed in the upper part of the intestine. Its peculiarity is that despite it being a simple molecule, this sugar is not metabolized by the organism. Consequently, it is not stored in the liver or other organs, but it is excreted unconverted into the urine via the kidneys. About 60 min after ingestion, it arrives unchanged in the urinary tract. D-mannose also has no effect on human metabolism after long-term use.”
Third, because of the natural way that D-Mannose works with bacteria, it does not negatively impact any other part of our system. “The anti-adhesive effect of D-mannose cannot be considered as a pharmacological effect: it interacts with bacterial constituents to promote (E Coli) washing out, but inducing neither a direct and measurable response in the microorganism, nor in the human beings. All these characteristics underline the fact that the long term use of D-mannose is safe.”
D-Mannose Does Not Interfere With Antibiotics
Another key finding from this review is that D-Mannose can be taken with antibiotics to produce faster results.
Here’s why: “D-mannose… inhibits the adhesion of bacteria to the urothelium (bladder lining). Binding free D-mannose, bacteria are blocked in the urine and then eliminated by the urinary tract… This effect is also present in the case of concurrent antibiotic therapy. In fact, D-mannose has no bacteriostatic and/or bactericidal activity and does not modify the bacterial cell, thus it does not interfere with the action of antibiotics.”